Interaction Checker

Interaction checker updates for January and February

Thursday 27 February 2025

Two new comedications have been added to the interaction checker - betamethasone (topical) has been added to the Steroids class and fosphenytoin has been added to the Anticonvulsant class.

Colour changes have also been made to the interactions listed below:

Nirmatrelvir/ritonavir (5 day)
↓ Red to Amber: Ciclosporin, Clonazepam, Clozapine, Everolimus, Lumateperone, Pethidine (Meperidine), Sirolimus, Tacrolimus
↓ Amber to Green: Piroxicam
↓ Yellow to Green: Chlorphenamine, Diphenhydramine, Ezetimibe, Fexofenadine, Gemfibrozil, Loratadine, Meclizine, Modafinil, Pitolisant
↑ Green to Amber: Lamotrigine, Retigabine
↑ Yellow to Amber: Sodium valproate, Valproate semisodium, Valproic acid

Nirmatrelvir/ritonavir (Extended Use)
↓ Red to Amber: Ciclosporin, Clonazepam, Clozapine, Lumateperone, Pethidine (Meperidine), Tacrolimus
↓ Amber to Green: Piroxicam
↓ Yellow to Green: Modafinil, Pitolisant
↑ Green to Amber: Retigabine

Fluvoxamine
↓ Amber to Green: Levetiracetam

Imatinib
↑ Yellow to Amber: Opipramol

Ensitrelvir
↓ Yellow to Green: Pitolisant

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